Quinine HCl Dihydrate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

盐酸奎宁二水合物是一种白色结晶 K+ 通道阻滞剂，用于治疗疟疾。

Quinine HCl Dihydrate is a white crystalline K+ channel blocker, used to treat malaria.

Cell Proliferation Assay Cell Line:Human hepatocarcinoma cell line(HepG2) Concentration:150 μM Incubation Time:30 min Result:Inhibited DENV virus replication with 19% yield compared to untreated. Reduced DENV-positive cells from 23.28% to 12.05% in a dose-dependent manner.

Animal Model:Swiss albino mice 7-8-weeks (weighing 24 g) Dosage:Swiss albino mice 7-8-weeks (weighing 24 g) Administration:Oral gavage; every week; 16 weeks Result:Resulted in a significant reduction in tumor size and weight at 12 mg/kg and little effect at higher dose of 15 mg/kg.

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GPCR/G Protein

SGLT

Potassium channel

Infection

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6119-47-7

396.91

C20H24N2O2·HCl·2H2O

>98% (HPLC)

DMSO : ≥ 100 mg/mL 251.95 mM H2O : 20 mg/mL50.39 mM;

O.O.Cl.[H][C@@]12CCN(C[C@@H]1C=C)[C@@]([H])(C2)[C@H](O)C1=CC=NC2=C1C=C(OC)C=C2

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(-20℃)

With Ice Pack

≥ 2 years